The Visine Prank was featured in the 2005 comedy Wedding Crashers based on an urban legend that a few drops into a person’s drink will cause diarrhea. This is NOT TRUE and in fact, ingestion of any of the topical imidazoline drugs can cause a serious and life threatening toxidrome. This video explains the Visine Prank, the mechanism of action of these drugs topically and the systemic effects that occur when the drug crosses the blood-brain barrier. Click the link to learn more!